What is the relationship between the 2021 Nobel Prize (medicine) and migraine, and what is Botox?

You may not know the story of the Nobel Prize because it does not appear in the media so much, but the 2021 Nobel Prize in Physiology or Medicine discovered an ion channel receptor that feels spicy (capsaicin). It was given to Professor Julius David of the University of California, San Francisco.

The previously unknown receptor for spiciness (capsaicin) is called TRPV1, and it was also found that if it is too irritating, it feels “painful”. This TRPV1 is also present in the trigeminal neuralgia model for pain, and it is thought that botulinum toxin preparations such as Botox suppress the reaction on the blood vessels and the surface membranes of the brain.

Furthermore, TRPV1 may be involved in the transmission of signals to the ganglia of the brain (thalamus) and spinal cord via receptors that detect changes in pressure, which are also suppressed by Clostridium botulinum toxin preparations. It has been suggested that it can be blocked by Botox.

We feel that the mechanism of Botox for migraine, which was not well understood until now, is being elucidated.

Wrinkles and Botox

Many people know that botulinum toxin preparations (such as Botox injection) are used to treat wrinkles. In the United States, it is widely used for treatments other than wrinkles, but I think that it is mainly used in the eyebrows, foreheads, crow’s feet, and hyperhidrosis of armpits in Japan.

Botox had been used in Japan and the US against the state where the eyebands are twitching more than before but in the United States it gets used for various facial expression wrinkles in the upper half of the face and then jaw muscle (slendering the face), temporomandibular disorder, hyperhidrosis (side arm and limb), and so on.

Details of Botox’s side effects and mechanism of action are described in detail on our website, but serious side effects are rare and representative ones include injection in wrinkles between the brows, it is found below 0.5% that eyelids are difficult to open (ptosis of the eyelids). Also, we can not treat pregnant, nursing or those planning to get pregnant.

Many patients are receiving this treatment because the treatment of wrinkles that can be easily done with a clinic easily and the price is relatively affordable (from 30,000 yen). In our clinic, patients with migraine also receive Botox treatment well (from 20,000 yen).

Botox for treatment of headaches

For treatment of migraine using botulinum toxin (Botox etc.), it is a subject of insurance treatment in Europe and the United States. If a patient is not abnormal by MRI or CT and a headache expert such as neurological department confirms diagnosis. Then, those people are being treated with peace of mind at almost all specialized medical institutions.

In Japan, it is unauthorized as an insurance treatment, so the doctor’s decision is left to the discretion, but our clinic’s guidelines are similar to those in the West. However, if local treatment is desired with mild migraine, we will also conduct partial treatment on a trial basis, so please consult us. In that case, the treatment cost is from 20,000 yen.

Migraine headaches and Botox treatment

In our clinic, treatment of migraine is done with botulinum toxin (Botox). This treatment is a treatment method approved by government agencies in Western countries such as the United States, Canada, UK, Australia. Prior to treatment we will check to see if it meets some standards.

First of all, doctors such as neurological department and neurosurgery undergo diagnosis of headaches such as migraine. Then, if possible, receiving image diagnosis such as CT or MRI in the past, it is possible to confirm that there is no abnormality, and so on. At the time of the first visit, if you bring a thing with a history list of medications and a history of treatment up to now, the procedure will be smooth.

Migraine headaches and Botox

For treatment of migraine with botulinum toxin (Botox etc.), it is subject to insurance treatment in Europe and the United States, if a patient has no abnormality with MRI etc, a definite diagnosis by a headache expert such as neurology internal medicine is made. These people are being treated with peace of mind at almost all specialized medical institutions.

In Japan, it is unauthorized as an insurance treatment, so the doctor’s decision is left to the discretion, but our clinic’s guidelines are similar to those in the West. However, if local treatment is desired with mild migraine, we will also conduct partial treatment on a trial basis, so please consult us. In that case, the treatment cost is from 20,000 yen.

For more details, please visit this page. Thank you.

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Dr. Kure





Plastic Surgeon in Tokyo Japan